Document Detail


Amiodarone: what have we learned from clinical trials?
MedLine Citation:
PMID:  10676597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amiodarone is an antiarrhythmic agent commonly used in the treatment of supraventricular and ventricular tachyarrhythmias. This paper reviews clinical trials in which amiodarone was used in one of the treatment arms. Key post-myocardial infarction trials include EMIAT and CAMIAT, both of which demonstrated that amiodarone reduced arrhythmic but not overall mortality. In patients with congestive heart failure (CHF), amiodarone was associated with a neutral survival in CHF/STAT and improvement in survival in GESICA. In patients with nonsustained ventricular tachycardia, the MADIT trial demonstrated that therapy with an implantable cardioverter-defibrillator (ICD) improved survival compared with the antiarrhythmic drug arm in such patients, most of whom were taking amiodarone. In sustained VT/VF patients, the CASCADE trial demonstrated that empiric amiodarone lowered arrhythmic recurrence rates compared with other drugs guided by serial Holter or electrophysiologic studies. Several trials including AVID, CIDS, and CASH have demonstrated the superiority of ICD therapy compared with empiric amiodarone in improving overall survival. Clinical implications of these trials are discussed.
Authors:
G V Naccarelli; D L Wolbrette; J T Dell'Orfano; H M Patel; J C Luck
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  23     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-07     Completed Date:  2000-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-82     Citation Subset:  IM    
Affiliation:
Section of Cardiology, Penn State University College of Medicine, Milton S. Hershey Medical Center, PennState Geisinger Health System, Hershey 17033, USA.
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MeSH Terms
Descriptor/Qualifier:
Amiodarone / therapeutic use*
Anti-Arrhythmia Agents / therapeutic use*
Clinical Trials as Topic
Death, Sudden, Cardiac / etiology,  prevention & control
Defibrillators, Implantable
Heart Failure / complications
Humans
Multicenter Studies as Topic
Myocardial Infarction / complications
Randomized Controlled Trials as Topic
Tachycardia, Ventricular / etiology,  therapy
Ventricular Dysfunction, Left / etiology,  therapy
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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