Document Detail


Amiodarone induced pneumonitis and hyperthyroidism: case report.
MedLine Citation:
PMID:  18846989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amiodarone is a highly effective antiarrhythmic agent used in life-threatening ventricular and supraventricular arrhythmias. Its long-term use may however lead to several adverse effects, including corneal deposits, liver and thyroid gland dysfunction, lung lesions, bone marrow injury, skin lesions, or neurological abnormalities. The article presents the case of a 56-year-old man with a history of a stroke, who after a few days of amiodarone therapy for an episode of atrial fibrillation was diagnosed with amiodarone-induced hyperthyroidism and interstitial pulmonary lesions. Clinical and laboratory symptoms of hyperthyroidism and radiographic signs of pulmonary involvement did not occur until several weeks after discontinuation of amiodarone therapy. Differential diagnosis of causes of hyperthyroidism and diseases causing nodular pulmonary lesions did not demonstrate any other pathologies. Empirical antibiotic therapy and administration of thiamazole and high doses of propranolol failed to improve the patient's clinical status. It was not until thiamazole was given in combination with glucocorticosteroids, when a slow relief of hyperthyroidism symptoms and resolution of radiographic pulmonary signs were observed. Based on the presented case, the risk of appearance of 2 serious concomitant adverse effects was demonstrated, even following a short-term amiodarone therapy. This paper also contains an overview of adverse effects which may be encountered during or after therapy with this effective antiarrhythmic agent. It was emphasized how important it is to select patients appropriately, and to monitor potential adverse effects during amiodarone therapy.
Authors:
Elzbieta Magdalena Grabczak; Tadeusz M Zielonka; Joanna Wiwa?a; Anna Dagmara Bare?a; Andrzej Opuchlik; Anna Potulska; Urszula Ambroziak; Ryszarda Chazan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewn?trznej     Volume:  118     ISSN:  0032-3772     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2009-01-14     Revised Date:  2010-04-01    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  524-9     Citation Subset:  IM    
Affiliation:
Chair and Department of internal Diseases, Pneumonology and Allergology, Warsaw Medical University, Warszawa, Poland. mgrabczak@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Amiodarone / administration & dosage,  adverse effects*
Anti-Arrhythmia Agents / administration & dosage,  adverse effects*
Atrial Fibrillation / etiology,  therapy*
Diagnosis, Differential
Humans
Hyperthyroidism / chemically induced*,  diagnosis
Lung Diseases, Interstitial / chemically induced*,  diagnosis
Male
Middle Aged
Pulmonary Alveoli / drug effects
Stroke / complications,  rehabilitation*
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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