| Amiodarone-induced hepatic phospholipidosis: a morphological alteration independent of pseudoalcoholic liver disease. | |
| | |
MedLine Citation:
|
PMID: 3417226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to study the relationship between amiodarone-induced hepatic phospholipidosis and liver disease, liver biopsies obtained from 13 patients treated with amiodarone for 4 months to 15 years were investigated by light and electron microscopy. Light microscopy showed pseudoalcoholic liver lesions that were probably related to amiodarone in four cases, various alterations (i.e. cirrhosis, three cases; steatosis and fibrosis, two cases; chronic venous congestion, one case; acute hepatitis, one case) that could be explained by another cause than amiodarone in seven cases and normal liver in two cases. In all cases, electron microscopy showed intralysosomal myelin figures suggestive of phospholipidosis. These myelin figures were associated with intralysosomal electron-dense deposits. In the four cases in which analysis by electron microprobe was performed, it demonstrated large amounts of iodine in the electron-dense deposit-containing lysosomes, indicating the accumulation of amiodarone. These results show that hepatic phospholipidosis is constantly observed in amiodarone-treated patients, whether or not pseudoalcoholic liver lesions are present. This phospholipidosis, which could be only a morphological marker of intrahepatic accumulation of the drug, should not therefore be considered grounds for attributing liver disease to the drug. |
| | |
Authors:
|
B Guigui; S Perrot; J P Berry; J Fleury-Feith; N Martin; J M Métreau; D Dhumeaux; E S Zafrani |
Related Documents
:
|
2014776 - Infarction in focal nodular hyperplasia of the liver. a case report. 16078496 - Blunt force injury of the abdomen complicating previously undiagnosed peliosis hepatis ... 8212976 - Hepatic artery aneurysm. case reports with review of the literature. 22728616 - Atypical onset and course in a child with fulminant myocarditis. 21880966 - Nineteen cases of buruli ulcer diagnosed in japan from 1980 to 2010. 23120366 - Macroglossia due to venous malformation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hepatology (Baltimore, Md.) Volume: 8 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1988 Sep-Oct |
Date Detail:
|
Created Date: 1988-10-27 Completed Date: 1988-10-27 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1063-8 Citation Subset: IM |
Affiliation:
|
Département de Pathologie Tissulaire et Cellulaire, Hôpital Henri Mondor, Créteil, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Amiodarone / adverse effects*, analysis Biopsy Dose-Response Relationship, Drug Drug-Induced Liver Injury* Electron Probe Microanalysis Female Histocytochemistry Humans Lipidoses / chemically induced*, metabolism, pathology Liver / analysis, drug effects, ultrastructure Liver Diseases / metabolism, pathology Liver Diseases, Alcoholic / etiology*, metabolism, pathology Male Middle Aged Phospholipids / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Phospholipids; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possibl...
Next Document: Biliary excretion in Sprague-Dawley and Gunn rats during manganese-bilirubin-induced cholestasis.