| Amiodarone--application and clinical pharmacology in atrial fibrillation and other arrhythmias. | |
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MedLine Citation:
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PMID: 6746145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty patients with atrial fibrillation (AF), 23 patients with ventricular extrasystoles (VES), and 11 patients with various arrhythmias (VA) were treated with amiodarone (0.2-0.6 g/day). Suppression of arrhythmia was 67.5% in AF, 78.2% in VES, and 81.8% in others with VA. Median age of converted patients was higher than that of nonconverted. The duration of AF before treatment was inversely related to drug efficacy. Average time needed for conversion was 6-8 days of treatment. Plasma amiodarone concentration at the day of conversion did not differ from that of nonconverted patients. Amiodarone concentration levels off after the 8th day of treatment, whereas that of the metabolite increases with time of treatment. Biologic half-life of plasma amiodarone after discontinuation of treatment varied, but was higher than 4 days. The percent of decline of the metabolite concentration was lower than that of the parent drug. |
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Authors:
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M Anastasiou-Nana; G M Levis; S D Moulopoulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology, therapy, and toxicology Volume: 22 ISSN: 0174-4879 ISO Abbreviation: Int J Clin Pharmacol Ther Toxicol Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-09-06 Completed Date: 1984-09-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003415 Medline TA: Int J Clin Pharmacol Ther Toxicol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 229-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amiodarone / blood, therapeutic use* Arrhythmias, Cardiac / drug therapy* Atrial Fibrillation / drug therapy* Benzofurans / therapeutic use* Electrocardiography Female Half-Life Humans Kinetics Male Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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