Document Detail

Amiodarone, adrenoceptor responsiveness and ischaemia- and reperfusion-induced arrhythmias.
MedLine Citation:
PMID:  1665418     Owner:  NLM     Status:  MEDLINE    
Experiments were performed in rats which had been pretreated with amiodarone 50 mg kg-1 day-1 p.o. for 4 weeks. In anaesthetized animals subject to 25 min of coronary artery occlusion, the rats which had received amiodarone had fewer ischaemia-induced ventricular premature beats than the controls (381 +/- 106 compared with 815 +/- 215, P = 0.070). The duration of arrhythmias induced by reperfusion following 5 min of ischaemia was also less in the rats which had received amiodarone than in the controls (43.8 +/- 6.8 and 16.0 +/- 3.1 s respectively). Pretreatment of rats with amiodarone reduced the maximum driving frequency of both isolated left atria and papillary muscles. There were no differences between the responses to alpha- or beta-adrenoceptor agonists or to calcium in papillary muscle preparations from amiodarone-pretreated and control rats. These results suggest that the antiarrhythmic activity of chronic amiodarone seen in the present study does not depend on changes in ventricular adrenoceptor responsiveness.
S J Coker; R Chess-Williams
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  201     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-04-03     Completed Date:  1992-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Department of Pharmacology and Therapeutics, University of Liverpool, U.K.
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MeSH Terms
Amiodarone / administration & dosage,  pharmacology*
Arrhythmias, Cardiac / etiology,  prevention & control*
Coronary Disease / complications*
Myocardial Contraction / drug effects
Myocardial Reperfusion Injury / complications*
Rats, Inbred Strains
Receptors, Adrenergic, beta / drug effects*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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