Document Detail

Amiodarone for the prevention of reperfusion ventricular fibrillation.
MedLine Citation:
PMID:  19800815     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the efficacy of prophylactic single-dose amiodarone administered through the pump circuit before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation (RVF).
DESIGN: A prospective, randomized double-blind, placebo-controlled efficacy study.
SETTING: A tertiary level teaching hospital.
INTERVENTION: Seventeen patients received 150 mg of amiodarone in 10 mL of normal saline by way of the pump 3 minutes before releasing the ACC, and a control group of 17 patients received 10 mL of normal saline.
MEASUREMENT AND MAIN RESULTS: The primary outcome of the study was the incidence of ventricular fibrillation requiring defibrillation during the 30-minute period after myocardial reperfusion. A large decrease in RVF (65% to 18%) was observed in the amiodarone-treated group with the number needed to treat only 2.1.The myocardial performance in terms of cardiac output was better in the amiodarone group; this could be attributed to the lower incidence of RVF and subsequent direct current shock therapy.
CONCLUSIONS: The observations showed that single-dose prophylactic amiodarone administered through the pump circuit 3 minutes before ACC release was an effective therapy to reduce the incidence of post-ACC release ventricular arrhythmias.
Aloka Samantaray; Abha Chandra; Sanjukta Panigrahi
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-10-02
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  24     ISSN:  1532-8422     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-11-08     Revised Date:  2011-02-22    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Anesthesiology and Critical Care, Sri Venkateswara Institute of Medical Sciences, Andhra Pradesh, India.
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MeSH Terms
Amiodarone / therapeutic use*
Double-Blind Method
Middle Aged
Myocardial Reperfusion / adverse effects*
Myocardial Reperfusion Injury / complications,  physiopathology,  prevention & control*
Prospective Studies
Ventricular Fibrillation / complications,  physiopathology,  prevention & control*
Reg. No./Substance:
Comment In:
J Cardiothorac Vasc Anesth. 2011 Feb;25(1):207   [PMID:  20188593 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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