| Amiodarone for the prevention of reperfusion ventricular fibrillation. | |
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MedLine Citation:
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PMID: 19800815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate the efficacy of prophylactic single-dose amiodarone administered through the pump circuit before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation (RVF). DESIGN: A prospective, randomized double-blind, placebo-controlled efficacy study. SETTING: A tertiary level teaching hospital. INTERVENTION: Seventeen patients received 150 mg of amiodarone in 10 mL of normal saline by way of the pump 3 minutes before releasing the ACC, and a control group of 17 patients received 10 mL of normal saline. MEASUREMENT AND MAIN RESULTS: The primary outcome of the study was the incidence of ventricular fibrillation requiring defibrillation during the 30-minute period after myocardial reperfusion. A large decrease in RVF (65% to 18%) was observed in the amiodarone-treated group with the number needed to treat only 2.1.The myocardial performance in terms of cardiac output was better in the amiodarone group; this could be attributed to the lower incidence of RVF and subsequent direct current shock therapy. CONCLUSIONS: The observations showed that single-dose prophylactic amiodarone administered through the pump circuit 3 minutes before ACC release was an effective therapy to reduce the incidence of post-ACC release ventricular arrhythmias. |
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Authors:
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Aloka Samantaray; Abha Chandra; Sanjukta Panigrahi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2009-10-02 |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 24 ISSN: 1532-8422 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-11-08 Revised Date: 2011-02-22 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 239-43 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Anesthesiology and Critical Care, Sri Venkateswara Institute of Medical Sciences, Andhra Pradesh, India. alokorissa@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amiodarone / therapeutic use* Double-Blind Method Female Humans Male Middle Aged Myocardial Reperfusion / adverse effects* Myocardial Reperfusion Injury / complications, physiopathology, prevention & control* Prospective Studies Ventricular Fibrillation / complications, physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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1951-25-3/Amiodarone |
| Comments/Corrections | |
Comment In:
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J Cardiothorac Vasc Anesth. 2011 Feb;25(1):207
[PMID:
20188593
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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