Document Detail


Amiodarone-Induced Thyrotoxic Thyroiditis: A Diagnostic and Therapeutic Challenge.
MedLine Citation:
PMID:  25477968     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Amiodarone is an iodine-based, potent antiarrhythmic drug bearing a structural resemblance to thyroxine (T4). It is known to produce thyroid abnormalities ranging from abnormal thyroid function testing to overt hypothyroidism or hyperthyroidism. These adverse effects may occur in patients with or without preexisting thyroid disease. Amiodarone-induced thyrotoxicosis (AIT) is a clinically recognized condition commonly due to iodine-induced excessive synthesis of thyroid, also known as type 1 AIT. In rare instances, AIT is caused by amiodarone-induced inflammation of thyroid tissue, resulting in release of preformed thyroid hormones and a hyperthyroid state, known as type 2 AIT. Distinguishing between the two states is important, as both conditions have different treatment implications; however, a mixed presentation is not uncommon, posing diagnostic and treatment challenges. We describe a case of a patient with amiodarone-induced type 2 hyperthyroidism and review the current literature on the best practices for diagnostic and treatment approaches.
Authors:
Umang Barvalia; Barkha Amlani; Ram Pathak
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-12
Journal Detail:
Title:  Case reports in medicine     Volume:  2014     ISSN:  1687-9627     ISO Abbreviation:  Case Rep Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-12-5     Completed Date:  -     Revised Date:  2014-12-6    
Medline Journal Info:
Nlm Unique ID:  101512910     Medline TA:  Case Rep Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  231651     Citation Subset:  -    
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