| Aminotriazole is a potent inhibitor of alpha-oxidation of 3-methyl-substituted fatty acids in rat liver. | |
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MedLine Citation:
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PMID: 7986209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The production of CO2 and formate in isolated rat hepatocytes incubated in the presence of 3-methyl[1-14C]margaric acid was investigated. Production rates of formate were approximately 4-fold lower than those of CO2. Aminotriazole (3-amino-1, 2, 4-triazole), an irreversible inhibitor of catalase, potently suppressed alpha-oxidation of 3-methylmargaric acid, whereas beta-oxidation of palmitate, 2-methylpalmitate and trihydroxycoprostanic acid and conversion of exogenously added formate to CO2 were not or only slightly affected. This shows that aminotriazole is not only an inhibitor of catalase, but also of alpha-oxidation of 3-methyl-substituted fatty acids. |
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Authors:
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M Casteels; K Croes; P P Van Veldhoven; G P Mannaerts |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical pharmacology Volume: 48 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-30 Completed Date: 1994-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1973-5 Citation Subset: IM |
Affiliation:
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Katholieke Universiteit Leuven, Afdeling Farmacologie, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amitrole
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pharmacology* Animals Catalase / antagonists & inhibitors Fatty Acids / metabolism* Liver / drug effects*, metabolism Male Methylation Oxidation-Reduction Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 61-82-5/Amitrole; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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