Document Detail


Aminotransferases and muscular diseases: A disregarded lesson. Case reports and review of the literature.
MedLine Citation:
PMID:  20500440     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of this study was to call the attention to the often disregarded message that hypertransaminasemia may be a marker of both liver and muscle diseases by presenting personal case reports and a systematic literature review. Three male children (mean age 5.7 years) were inappropriately addressed, during the last 12 months, to our paediatric liver unit for diagnostic work-up of a chronic hypertransaminasemia of unknown origin. In one of them, a liver biopsy had already been performed. On admission, physical examination, evaluation of serum levels of creatine kinase, and dystrophin genetic testing finally led to a diagnosis of muscular dystrophy. One hundred fourteen similar cases, 21 with unnecessary liver biopsy, were found by Medline search. Expensive and invasive tests planned to investigate liver diseases should be postponed until alternative sources of increased serum aminotransferases, primarily myopathic injury, have been excluded.
Authors:
Claudio Veropalumbo; Ennio Del Giudice; Gabriella Esposito; Sergio Maddaluno; Lucia Ruggiero; Pietro Vajro
Publication Detail:
Type:  Journal Article     Date:  2010-05-24
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  48     ISSN:  1440-1754     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  886-90     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of Paediatrics and Child Health © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
Affiliation:
Pediatric Liver and Neurology Units of the Department of Pediatrics, Department of Biochemistry and Medical Biotechnology, Biotecnologie Avanzate, CEINGE and Department of Neurological Sciences, University of Naples 'Federico II', Napoli, Italy.
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