Document Detail


Aminotransferase as a prognostic index in infants with liver disease.
MedLine Citation:
PMID:  2302779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the utility of the serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio in a group of infants with liver disorders, we retrospectively analyzed the charts of 73 infants with chronic liver disorders. Patients were considered as having either a good outcome (n = 40) or a poor outcome (n = 33), based upon the clinical course. AST and ALT in serum were measured simultaneously at the time of initial presentation and at various follow-up visits during the first 13 months after birth. At presentation (mean age 1.65 months), there was no difference in the AST/ALT ratios between the good (1.61 +/- 0.62; mean +/- SD) and poor (1.65 +/- 0.78) outcome groups (P = 0.81). However, over time, the AST/ALT ratio increased in patients in the poor-outcome group and decreased in patients in the good-outcome group. Calculating the AST/ALT ratio appears to be an easy, early, and reliable prognostic indicator for infants with hepatic disease, and may be a useful measure for evaluating liver-disease patients.
Authors:
P Rosenthal; M Haight
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  36     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-23     Completed Date:  1990-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Childrens Hospital of Los Angeles, CA.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Liver Diseases / enzymology*
Male
Prognosis
Retrospective Studies
Chemical
Reg. No./Substance:
EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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