| Aminothiol redox alterations in patients with chronic heart failure of ischaemic or non-ischaemic origin. | |
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MedLine Citation:
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PMID: 18163014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Oxidative stress plays a role in the progression of chronic heart failure (CHF), but whether and how ischaemic heart disease (IHD) or non-IHD aetiology may account for differential redox alterations is currently unclear. We assessed the relation between thiol redox state and lipid peroxidation, as a marker of oxidative stress, in patients with CHF of ischaemic or non-ischaemic origin. METHODS: Blood reduced glutathione, plasma total and reduced cysteine, cysteinylglycine, homocysteine, glutathione, plasma alpha-tocopherol, ascorbic acid, and free malondialdehyde were assessed in 43 CHF heart transplant candidates (24 IHD and 19 non-IHD) and 30 controls matched for age, gender and number of atherosclerotic risk factors. RESULTS: Reduced cysteine was increased in CHF patients compared with controls. The highest levels were found in IHD versus non-IHD patients versus controls. Malondialdehyde levels were significantly higher in IHD patients than in controls, whereas antioxidant vitamins did not differ among the three groups. CONCLUSIONS: Specific abnormalities in the thiol pattern are associated with heart failure aetiology in CHF patients. Our findings point to the possible role of reduced cysteine in the progression of chronic IHD to heart failure status, as an additional pro-oxidant stimulus for worsening oxidative stress. |
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Authors:
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Jonica Campolo; Raffaele Caruso; Renata De Maria; Marina Parolini; Fabrizio Oliva; Elena Roubina; Giuliana Cighetti; Maria Frigerio; Ettore Vitali; Oberdan Parodi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: 8 ISSN: 1558-2027 ISO Abbreviation: J Cardiovasc Med (Hagerstown) Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-28 Completed Date: 2008-01-24 Revised Date: 2009-05-28 |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: United States |
Other Details:
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Languages: eng Pagination: 1024-8 Citation Subset: IM |
Affiliation:
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CNR Clinical Physiology Institute of Milan, Cardiology Department, Niguarda Ca Granda Hospital, Milan, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ascorbic Acid / blood Biological Markers / blood Case-Control Studies Chronic Disease Cysteine / blood Dipeptides / blood Disease Progression Female Glutathione / blood Heart Failure / blood*, etiology Homocysteine / blood Humans Lipid Peroxidation* Male Malondialdehyde / blood Middle Aged Myocardial Ischemia / blood, complications* Oxidation-Reduction Oxidative Stress* Research Design Sulfhydryl Compounds / blood* alpha-Tocopherol / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dipeptides; 0/Sulfhydryl Compounds; 19246-18-5/cysteinylglycine; 454-28-4/Homocysteine; 50-81-7/Ascorbic Acid; 52-90-4/Cysteine; 542-78-9/Malondialdehyde; 59-02-9/alpha-Tocopherol; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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