| Aminoterminal B-type natriuretic peptide (NT-proBNP) in the therapy of patent ductus arteriosus. | |
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MedLine Citation:
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PMID: 21089722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: NT-proBNP is a reliable index in case of cardiac diseases. OBJECTIVE: To evaluate the diagnostic usefulness of NT-proBNP as index of the closure of patent ductus arteriosus (PDA) in ELBW. METHODS: Considered 73 ELBW (mGA 26+3 weeks; mBW 789 g) with echocardiographical diagnosis of PDA. The closure of the duct was spontaneous in 22%, pharmacological in 49.3% and by surgical ligation in 28.7%. Plasma NT-proBNP levels were measured on day 3 in 35 preterm infants; in 20 of them concentrations of the peptide were assayed on day 3 and on closure of the duct. RESULTS: On day 3 the median of NT-proBNP levels was 13718 pg/ml (range 1918-70000). Peptide concentrations did not differ between pharmacological treatment and surgical ligation (respectively 13718 and 12342 pg/ml; p = 0.33). Concentrations of NT-proBNP were significantly lower on the closure of the duct (p < 0.0001) compared to concentrations on day 3 (median 12666 at day 3 versus 2443.5 pg/ml at closure), with a decrease of 80.71%. CONCLUSIONS: ELBW showed high variability of NT-proBNP concentrations both on day 3 and on closure of PDA. Although NT-proBNP high levels were indicative of the presence of hsPDA, due to the extreme heterogeneity of the values it was not possible to determine an absolute cut-off concentration of NT-proBNP below which closure of the duct occurred, while a decrease of NT-proBNP > or =80% was a reliable index of PDA closure. |
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Authors:
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F Bagnoli; A Rossetti; M Casucci; A Mori |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Minerva pediatrica Volume: 62 ISSN: 0026-4946 ISO Abbreviation: Minerva Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-11-22 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400740 Medline TA: Minerva Pediatr Country: Italy |
Other Details:
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Languages: eng Pagination: 67-70 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Obstetrics and Reproduction Medicine, Neonatal Intensive Care, University of Siena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Ductus Arteriosus, Patent / blood*, complications, drug therapy, surgery Female Gestational Age Humans Ibuprofen / therapeutic use Infant, Extremely Low Birth Weight Infant, Newborn Infant, Premature, Diseases / blood*, drug therapy, surgery Ligation Male Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prognosis Remission, Spontaneous Renal Insufficiency / complications Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 15687-27-1/Ibuprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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