Document Detail

Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma.
MedLine Citation:
PMID:  2862819     Owner:  NLM     Status:  MEDLINE    
We studied 40 patients with acute exacerbations of asthma to determine the efficacy of a 3-h intravenous infusion of aminophylline in patients who were already being treated with an inhaled beta-adrenergic agonist (metaproterenol). Each patient was treated with inhaled metaproterenol at hourly intervals for 3 h. In addition, patients were randomly assigned to therapy with either intravenous aminophylline or placebo. Neither the patient nor the house officers and nurses caring for the patient knew whether aminophylline or placebo was given. The FEV1 improved continually throughout the study to a similar extent in both treatment groups, but the patients treated with aminophylline had significantly more adverse effects (p less than 0.025, Mann-Whitney). There was no apparent benefit from aminophylline even in patients who presented to the emergency room with severe airway obstruction (FEV1 less than 0.8L) or with plasma theophylline levels less than 10 mg/L. We conclude that intravenous aminophylline adds to the toxicity but not the efficacy of inhaled metaproterenol in the treatment of acute exacerbations of asthma.
D Siegel; D Sheppard; A Gelb; P F Weinberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  132     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-12     Completed Date:  1985-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenergic beta-Agonists / administration & dosage*,  adverse effects
Aminophylline / administration & dosage,  adverse effects*
Asthma / drug therapy*
Drug Therapy, Combination
Forced Expiratory Volume
Infusions, Parenteral
Middle Aged
Orciprenaline / administration & dosage,  adverse effects
Theophylline / blood
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Aerosols; 317-34-0/Aminophylline; 58-55-9/Theophylline; 586-06-1/Orciprenaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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