| Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses. | |
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MedLine Citation:
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PMID: 9030406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II increases drinking and blood pressure when administered intracerebroventricularly. Intracerebroventricular injections of antiserum with anticatalytic activity against aminopeptidase A, the principal enzyme that metabolizes angiotensin II to angiotensin III, reduced the drinking and blood pressure responses to 10 pmol angiotensin II by 73% and 59%, respectively. APA antiserum had no effect on responses to angiotensin III administered intracerebroventricularly. A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking. These results suggest that metabolism of angiotensin II to angiotensin III is an obligatory activation step for the brain angiotensin system. |
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Authors:
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L Song; S Wilk; D P Healy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 744 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-15 Completed Date: 1997-04-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York, NY 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminopeptidases
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immunology* Angiotensin II / immunology, pharmacology* Angiotensin III / immunology, pharmacology Animals Antibodies, Blocking / pharmacology Antibody Specificity Blood Pressure / drug effects Brain / drug effects, enzymology* Glutamyl Aminopeptidase Injections, Intraventricular Male Metalloendopeptidases / immunology Rats Rats, Sprague-Dawley Vasoconstrictor Agents / immunology, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL42585/HL/NHLBI NIH HHS; HL50685/HL/NHLBI NIH HHS; NS17392/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Blocking; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 12687-51-3/Angiotensin III; EC 3.4.11.-/Aminopeptidases; EC 3.4.11.7/Glutamyl Aminopeptidase; EC 3.4.24.-/Metalloendopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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