| Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus. | |
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MedLine Citation:
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PMID: 20835596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effect of aminoguanidine on pulmonary oxidative stress and lung structure in an experimental model of diabetes mellitus. Thiobarbituric acid reactive substances (TBARS), histology and arterial blood gases were evaluated in animals with diabetes mellitus (DM group), animals with diabetes mellitus treated with aminoguanidine (DM+AG group), and controls. The TBARS levels were significantly higher in the DM group than in the control and DM+AG groups (2.90 ± 1.12 vs. 1.62 ± 0.28 and 1.68 ± 0.04 nmol/mg protein, respectively), as was PaCO2 when compared with that of the control group (49.2 ± 1.65 vs. 38.12 ± 4.85 mmHg), and PaO2 was significantly higher in the control group (104.5 ± 6.3 vs. 16.30 ± 69.48 and 97.05 ± 14.02 mmHg, respectively). In this experimental model of diabetes mellitus, aminoguanidine reduced oxidative stress, structural tissue alterations, and gas exchange. |
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Authors:
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Fabio Cangeri Di Naso; Luiz Alberto Forgiarini Junior; Luiz Felipe Forgiarini; Marilene Porawski; Alexandre Simões Dias; Norma Anair Possa Marroni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia Volume: 36 ISSN: 1806-3756 ISO Abbreviation: J Bras Pneumol Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-05-13 Revised Date: 2011-10-11 |
Medline Journal Info:
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Nlm Unique ID: 101222274 Medline TA: J Bras Pneumol Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 485-9 Citation Subset: IM |
Affiliation:
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Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Diabetes Mellitus, Experimental / drug therapy*, pathology* Guanidines / pharmacology* Oxidative Stress / drug effects* Random Allocation Rats Rats, Wistar Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Guanidines; 0/Thiobarbituric Acid Reactive Substances |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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