| Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. | |
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MedLine Citation:
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PMID: 1376704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased blood flow and vascular leakage of proteins preferentially affect tissues that are sites of diabetic complications in humans and animals. These vascular changes in diabetic rats are largely prevented by aminoguanidine. Glucose-induced vascular changes in nondiabetic rats are also prevented by aminoguanidine and by NG-monomethyl-L-arginine (NMMA), an established inhibitor of nitric oxide (NO.) formation from L-arginine. Aminoguanidine and NMMA are equipotent inhibitors of interleukin-1 beta-induced 1) nitrite formation (an oxidation product of NO.) and cGMP accumulation by the rat beta-cell insulinoma cell line RINm5F, and 2) inhibition of glucose-stimulated insulin secretion and formation of iron-nitrosyl complexes by islets of Langerhans. In contrast, NMMA is approximately 40 times more potent than aminoquanidine in elevating blood pressure in nondiabetic rats. These results demonstrate that aminoguanidine inhibits NO. production and suggest a role for NO. in the pathogenesis of diabetic vascular complications. |
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Authors:
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J A Corbett; R G Tilton; K Chang; K S Hasan; Y Ido; J L Wang; M A Sweetland; J R Lancaster; J R Williamson; M L McDaniel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 41 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-07-23 Completed Date: 1992-07-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 552-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Oxidoreductases
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antagonists & inhibitors,
metabolism Animals Arginine / analogs & derivatives, pharmacology Blood Pressure / drug effects Blood Vessels / drug effects Cells, Cultured Diabetic Angiopathies / etiology, metabolism, prevention & control* Enzyme Activation / drug effects, physiology Glucose / pharmacology Guanidines / pharmacology* Insulin / metabolism Interleukin-1 / pharmacology Islets of Langerhans / cytology, drug effects, metabolism Male Nitric Oxide / antagonists & inhibitors, metabolism* Nitric Oxide Synthase Rats Rats, Inbred Strains Regional Blood Flow / drug effects omega-N-Methylarginine |
| Grant Support | |
ID/Acronym/Agency:
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DK-06181/DK/NIDDK NIH HHS; EY-06600/EY/NEI NIH HHS; T32 DK-07296/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Guanidines; 0/Interleukin-1; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; 17035-90-4/omega-N-Methylarginine; 50-99-7/Glucose; 74-79-3/Arginine; 79-17-4/pimagedine; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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