Document Detail

Aminoglycoside resistance among blood culture isolates.
MedLine Citation:
PMID:  6378968     Owner:  NLM     Status:  MEDLINE    
A total of 633 blood culture isolates were collected from 1981 to 1982 from seven major Finnish hospitals, including all university central hospitals. Susceptibility of the strains to gentamicin, tobramycin, amikacin, and netilmicin was determined by the Sensititre microtiter procedure. Resistance against any of these agents occurred in 1.3 to 6.5% of all strains studied. In the Turku University Central Hospital, an increased number of tobramycin- and gentamicin-resistant Staphylococcus epidermidis were found; the frequency of strains resistant to tobramycin was 57% and to gentamicin was 29% versus frequencies of 16 and 18%, respectively, which were observed in the other hospitals. An explanation for this might be a change in the use of aminoglycosides in the Turku University Central Hospital; within 3 years, 1979 to 1981, the consumption of tobramycin and amikacin had increased 330 and 290%, respectively, whereas the use of gentamicin had decreased to 24% of that in the beginning of the period. Resistance against tobramycin was mediated by enzymes APH(2")-AAC(6') and ANT(4').
P Huovinen; P Grönroos; E Herva; M L Katila; M L Klossner; O V Renkonen; P Toivanen
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  20     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-27     Completed Date:  1984-08-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-9     Citation Subset:  IM    
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MeSH Terms
Amikacin / pharmacology
Aminoglycosides / pharmacology
Anti-Bacterial Agents / pharmacology*
Blood / microbiology*
Drug Resistance, Microbial
Enterobacteriaceae / drug effects*
Escherichia coli / drug effects
Gentamicins / pharmacology
Klebsiella / drug effects
Netilmicin / pharmacology
Proteus mirabilis / drug effects
Pseudomonas / drug effects*
Staphylococcus / drug effects*
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects
Tobramycin / pharmacology
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Gentamicins; 32986-56-4/Tobramycin; 37517-28-5/Amikacin; 56391-56-1/Netilmicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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