Document Detail


Aminoglycoside peritoneal lavage: lack of efficacy in experimental fecal peritonitis.
MedLine Citation:
PMID:  4057024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The utility of an adjunctive aminoglycoside lavage in the prevention of intra-abdominal abscesses utilizing an experimental rodent model was studied. Peritonitis was created in 115 rats by the intra-abdominal placement of gelatin capsules containing a barium-sulfate, human stool mixture. Four hours later, the animals were re-explored and lavaged with 30 ml/kg of sterile saline. Following the lavage, they were randomized to receive 15 ml/kg of either a 0.2% gentamicin or a normal saline lavage. The animals were then treated with intramuscular gentamicin-clindamycin or saline placebo for nine days. There was no difference in the number of abscesses between the groups receiving systemic antibiotics. The addition of gentamicin to a peritoneal lavage did not decrease the incidence of intra-abdominal infection in animals receiving effective systemic antibiotics.
Authors:
K P Lally; L D Shorr; R L Nichols
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  20     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-16     Completed Date:  1985-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abdomen*
Abscess / etiology,  prevention & control*
Aminoglycosides / therapeutic use*
Animals
Clindamycin / administration & dosage,  therapeutic use
Drug Combinations
Feces
Gentamicins / administration & dosage,  therapeutic use
Humans
Infusions, Parenteral
Irrigation
Male
Peritonitis / complications*
Random Allocation
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Drug Combinations; 0/Gentamicins; 18323-44-9/Clindamycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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