Document Detail


Aminoglycoside ototoxicity.
MedLine Citation:
PMID:  17823553     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies. RECENT FINDINGS: Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory epithelium after aminoglycoside administration and methods of blocking reactive oxygen species in the cochlea have been attempted, but not found to be uniformly effective in protecting against cell loss or threshold shift. Aspirin has recently been studied in a human chemoprevention trial in China, and while data suggest the possibility of protection, there was a significant increase in gastrointestinal bleeds associated with aspirin use. SUMMARY: There are currently no recommendations for pretreatment or posttreatment therapies to attenuate ototoxicity associated with aminoglycoside antibiotics. Our understanding of the mechanisms of ototoxicity has improved and apoptotic pathways are clearly responsible for hair cell demise. Further studies are necessary before significant improvement in hearing outcome can be expected after use of ototoxic antibiotics.
Authors:
Mark Douglas Rizzi; Keiko Hirose
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in otolaryngology & head and neck surgery     Volume:  15     ISSN:  1068-9508     ISO Abbreviation:  Curr Opin Otolaryngol Head Neck Surg     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417024     Medline TA:  Curr Opin Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Affiliation:
Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides / adverse effects*,  pharmacology
Anti-Bacterial Agents / adverse effects*,  pharmacology
Apoptosis / drug effects
Genetic Predisposition to Disease
Hair Cells, Auditory / drug effects
Hearing Loss, Sensorineural / chemically induced*
Humans
Mutation
Tinnitus / chemically induced
Vestibular Diseases / chemically induced*
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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