Document Detail


Aminoglycoside antibiotics and lysosomal enzymes of human tears.
MedLine Citation:
PMID:  4062644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined biochemically the effect of six aminoglycoside antibiotics on the activity of lysozyme, acid phosphatase, and N-acetyl-beta-D-glucosaminidase in human tears. All six antibiotics strongly inhibited lysozyme activity, the degree of inhibition depending on the dose administered. Except for bekanamycin, antibiotics had little effect on the activity of acid phosphatase or N-acetyl-beta-D-glucosaminidase. The nature of the inhibition was competitive. Other kinds of antibiotics, such as sulbenicillin or erythromycin, had no inhibitory effect on lysozyme, acid phosphatase, or N-acetyl-beta-D-glucosaminidase. These results suggested that the inhibition of lysozyme by aminoglycosides is specific and that the decreased effectiveness of a protective system against bacterial infection in the eye is highly possible when aminoglycoside antibiotics are used without prior sensitivity testing.
Authors:
T Shiono; S Hayasaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  103     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-26     Completed Date:  1985-11-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1747-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / metabolism*
Acid Phosphatase / metabolism*
Amikacin / pharmacology
Aminoglycosides / pharmacology
Anti-Bacterial Agents / pharmacology*
Depression, Chemical
Dibekacin / pharmacology
Erythromycin / pharmacology
Gentamicins / pharmacology
Hexosaminidases / metabolism*
Humans
Kanamycin / analogs & derivatives,  pharmacology
Muramidase / metabolism*
Sulbenicillin / pharmacology
Tears / drug effects*,  enzymology
Tobramycin / pharmacology
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Gentamicins; 114-07-8/Erythromycin; 32986-56-4/Tobramycin; 34493-98-6/Dibekacin; 37517-28-5/Amikacin; 41744-40-5/Sulbenicillin; 4696-76-8/bekanamycin; 52093-21-7/micronomicin; 59-01-8/Kanamycin; EC 3.1.3.2/Acid Phosphatase; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.17/Muramidase; EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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