| Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm. | |
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MedLine Citation:
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PMID: 12745015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several aminocarboxylate complexes of the "no carrier added" (NCA) radiolanthanides (149)Pm, (166)Ho and (177)Lu were evaluated using our in vitro hydroxyapatite and serum stability model and in vivo in normal CF-1 mice [10]. The aminocarboxylate chelates evaluated with the NCA radiolanthanides for in vitro stability were EDTA, CDTA, DTPA, MA-DTPA and DOTA. In addition, the NCA radiolanthanide complexes with DTPA-octreotide (DTPA-OCT) were synthesized and evaluated, as a model for a peptide conjugated aminocarboxylate complex. The biodistribution studies of the NCA complexes with DTPA, DOTA and DTPA-OCT showed that the in vitro model correctly predicted the in vivo stability of the radiolanthanide complexes, with Ln-DOTA > Ln-DTPA > Ln-DTPA-OCT. |
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Authors:
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Wen Ping Li; C Jeff Smith; Cathy S Cutler; Timothy J Hoffman; Alan R Ketring; Silvia S Jurisson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 30 ISSN: 0969-8051 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-14 Completed Date: 2003-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 241-51 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Missouri, Columbia, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chelating Agents / pharmacology Drug Stability Half-Life Holmium / blood, chemistry, pharmacokinetics Humans Lutetium / blood, chemistry, pharmacokinetics Mice Octreotide / blood, chemistry*, pharmacokinetics Promethium / blood, chemistry, pharmacokinetics Radioisotopes / blood, chemistry*, pharmacokinetics Radiopharmaceuticals / blood, chemistry*, pharmacokinetics Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Radioisotopes; 0/Radiopharmaceuticals; 7439-94-3/Lutetium; 7440-12-2/Promethium; 7440-60-0/Holmium; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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