Document Detail

Aminocaproic acid in prolonged hematuria of patients with sicklemia.
MedLine Citation:
PMID:  1275623     Owner:  NLM     Status:  MEDLINE    
Forty-four episodes of sicklemic hematuria occurring in 40 patients during a 12-year period were reviewed. Seven of seven patients had evidence of a hyperactive fibrinolytic system. Fifteen of 38 pyelograms demonstrated obstruction of some portion of the collecting system by blood clots that cleared on follow-up studies (nine patients) in 2 to 37 days. Hematuria subsided spontaneously in 20 episodes. Aminocaproic acid was used in 22 patients whose hematuria prior to aminocaproic acid administration averaged twice as long as the total duration in patients undergoint spontaneous remission. Hematuria subsided in 2.2 +/- 0.3 days in the group treated with aminocaproic acid. Therapy with aminocaproic acid in this study was not associated with an increased incidence of thrombosis. Because of its potential untoward effects, however, EACA therapy in this disorder should be limited to patients with severe or prolonged hematuria.
W D Black; F E Hatch; S Acchiardo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  136     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  678-81     Citation Subset:  AIM; IM    
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MeSH Terms
Aminocaproic Acids / adverse effects,  therapeutic use*
Anemia, Sickle Cell / complications*
Child, Preschool
Drug Evaluation
Hematuria / drug therapy*
Middle Aged
Remission, Spontaneous
Thrombosis / chemically induced
Time Factors
Reg. No./Substance:
0/Aminocaproic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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