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Aminoaciduria, but normal thyroid hormone levels and signaling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.
MedLine Citation:
PMID:  21726201     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The system L amino acid transporter 2 (LAT2) is composed of the subunits Slc7a8/Lat2 and Slc3a2/4F2hc. This transporter is highly expressed along the basolateral membranes of absorptive epithelia in kidney and small intestine, but is also abundant in the brain. Lat2 is an energy-independent exchanger of neutral amino acids, and was shown to transport thyroid hormones. We report here that targeted inactivation of Slc7a8 leads to increased urinary loss of small neutral amino acids. Development and growth of Slc7a8-/- mice appears normal suggesting functional compensation of neutral amino acid transport by alternative transporters in kidney, intestine, and placenta. Movement coordination is slightly impaired in mutant mice, although cerebellar development and structure remained inconspicuous. Circulating thyroid hormones, thyrotropin, and thyroid hormone-responsive genes remained unchanged in Slc7a8-/- mice, possibly because of functional compensation by the thyroid hormone transporter Mct8, which is co-expressed in many cell types. The reason for the mild neurological phenotype remains unresolved.
Authors:
Doreen Braun; Eva K Wirth; Franziska Wohlgemuth; Nathalie Reix; Marc O Klein; Annette Grüters; Josef Köhrle; Ulrich Schweizer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-4
Journal Detail:
Title:  The Biochemical journal     Volume:  -     ISSN:  1470-8728     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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