Document Detail


Aminoaciduria as a marker of acute renal transplant rejection--a patient study.
MedLine Citation:
PMID:  1905600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over 12 months, urine samples were systematically collected from 40 children who underwent renal transplantation for the treatment of end-stage renal disease. Sequential determinations of the excretion of individual amino acids relative to that of creatinine were carried out on 15 subjects. Nine of these (including three who sustained episodes of acute rejection) retained a native kidney in-situ, while in six patients (including three who underwent an episode of acute rejection) both native kidneys had been removed. In both subgroups, the amino acid/creatinine ratios of early morning urine samples were higher shortly before clinical manifestations of acute rejection became evident than in patients who, following renal transplantation, had stable kidney function, chronic graft rejection, or acute tubular necrosis, with one exception: a patient with one native kidney in-situ in whom acute tubular necrosis developed immediately after transplantation. The amino acids showing the greatest increase included Thr, Ser, Gly, and Ala. These values fell dramatically immediately prior to the clinical episode of acute rejection, with Thr, Ala, and Phe showing the most consistent changes. These alterations in urinary amino acid excretion occurred several days before changes in urinary protein excretion or the serum concentrations of urea and creatinine, and may have a role to play in the monitoring of renal transplant recipients.
Authors:
N A Macpherson; M A Moscarello; D M Goldberg; N Ish-Shalom; G S Arbus
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  14     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-05     Completed Date:  1991-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  111-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Hospital for Sick Children, Toronto, Ontario.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alanine / urine
Amino Acids / urine*
Child
Child, Preschool
Creatinine / urine
Female
Glycine / urine
Graft Rejection*
Humans
Kidney Failure, Chronic / surgery
Kidney Transplantation*
Male
Serine / urine
Threonine / urine
Chemical
Reg. No./Substance:
0/Amino Acids; 56-40-6/Glycine; 56-41-7/Alanine; 56-45-1/Serine; 60-27-5/Creatinine; 72-19-5/Threonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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