Document Detail


Amino thiols, detoxification and oxidative stress in pre-eclampsia and other disorders of pregnancy.
MedLine Citation:
PMID:  15777228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New knowledge of placental development and function suggests that several common complications of pregnancy could share a similar origin. It is suggested that impaired placental development in early pregnancy may lead to placental oxidative stress and subsequently to the maternal syndromes such as recurrent early pregnancy loss and pre-eclampsia. Oxidative stress has been most extensively investigated in pre-eclampsia, resulting in hundreds of publications and many reviews. In general the literature points to the presence of placental and maternal oxidative stress. However, conformity amongst the relevant data is not absolute, most probably the result of the diversity of biomarkers investigated and the methods employed to assess oxidative stress, which generally depend on the assessment of end products of oxidative stress. Recently, new techniques have been developed that use different approaches based on the "real-time" measurement of oxidative stress by the redox status of thiols or the assessment of superoxide generation, whereas the role of Phase I/Phase II biotransformation pathways in oxidative stress was recognised. This review focuses on this biotransformation system, the thiol redox status and the involvement of these systems in oxidative stress associated with reproduction and pregnancy disorders, with the emphasis being laid on the syndrome of pre-eclampsia.
Authors:
M T M Raijmakers; W H M Peters; E A P Steegers; L Poston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  11     ISSN:  1381-6128     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-21     Completed Date:  2005-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  711-34     Citation Subset:  IM    
Affiliation:
Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, St. Thomas' Hospital, London, SE1 7EH, UK. maarten.raijmakers@kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Glutathione / metabolism
Humans
Infertility / physiopathology
Oxidative Stress / physiology*
Pre-Eclampsia / metabolism,  physiopathology*
Pregnancy
Pregnancy Complications / metabolism,  physiopathology*
Sulfhydryl Compounds / therapeutic use*
Superoxides / metabolism
Chemical
Reg. No./Substance:
0/Sulfhydryl Compounds; 11062-77-4/Superoxides; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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