Document Detail

Amino-terminal pro-B-type brain natriuretic Peptide: screening for cardiovascular disease in the setting of alcoholism.
MedLine Citation:
PMID:  21508196     Owner:  NLM     Status:  In-Data-Review    
AIMS: N-terminal pro-BNP (NtBNP) has attracted attention as a biomarker for heart failure. The aims of our study are (a) to characterize the role of NtBNP as a biological marker in the setting of alcoholism; (b) to describe potential gender differences with respect to NtBNP; (c) to correlate NtBNP with other clinical and haemodynamic variables.
METHODS: We examined 83 alcohol-dependent patients according to International Classification of Disease 10th Revision (ICD-10) and Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV; 59 males and 24 females, age: 50 ± 10.5 years) referred to the department of psychiatry for alcohol withdrawal therapy. In these patients, we determined NtBNP, markers of alcohol abuse and transthoracic echocardiography to determine systolic left ventricular ejection fraction (EF). These measurements were repeated after alcohol withdrawal.
RESULTS: At Day 1 of alcohol withdrawal, 43 patients (52%; 27 males and 16 females) had elevated NtBNP levels (394.4 ± 438.7 pg/ml) despite normal EF (64.7 ± 6.2%). After withdrawal therapy (16.6 ± 7.8 days), NtBNP decreased significantly (228.6 ± 251.2 pg/ml; P < 0.01), despite unchanged EF (65.0 ± 5.8%; P = ns). This was the case in both males and females (328.9 ± 235.5 to 216.7 ± 194.3 pg/ml; P < 0.05 vs. 492.7 ± 635.7 to 246.6 ± 327.7 pg/ml; P < 0.05). Elevated NtBNP levels were related significantly to the history of arterial hypertension (P < 0.05).
CONCLUSION: This study highlights the fact that NtBNP can be elevated in the setting of alcoholism. The elevation in NtBNP is unrelated to EF and is reversible after alcohol withdrawal. We suggest a subclinical detrimental effect of alcohol abuse on cardiac function.
Peter Höfer; Bonni Syeda; Jutta Bergler-Klein; Fabian Friedrich; Otto Michael Lesch; Benjamin Vyssoki; Thomas Binder; Henriette Walter
Related Documents :
7943686 - Carbohydrate-deficient transferrin and gamma-glutamyltransferase as markers of heavy al...
2765196 - Reasons for alcohol use by female heavy, moderate, and occasional social drinkers.
7771666 - Variation in the association of alcohol consumption with five dsm-iv alcohol problem do...
9415206 - The pharmacoepidemiological phenomenon of age-dependent drug consumption and analysis o...
24409036 - The effect of scoliosis angle on center of gravity sway.
147046 - Down syndrome, paternal age, maternal age and birth order.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  46     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-04-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Corresponding author.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biological mechanisms in alcohol dependence--new perspectives.
Next Document:  Age, period and cohort analysis of light and binge drinking in Finland, 1968-2008.