| Amino-terminal fragment of pro-brain natriuretic hormone identifies functional impairment and right ventricular overload in operated tetralogy of Fallot patients. | |
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MedLine Citation:
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PMID: 17607499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the relationship between plasma concentration of amino-terminal fragment of pro-brain natriuretic peptide (NT-proBNP), functional capacity, and right ventricular overload in survivors of tetralogy of Fallot (TOF) repair, we prospectively studied 70 operated TOF patients (44 males, 21 +/- 1 years old; mean +/- SEM) who underwent, during the same day, echocardiography, cardiac magnetic resonance imaging, neurohormonal characterization (plasma NT-proBNP, catecholamines, plasma renin activity, and aldosterone assay), and cardiopulmonary exercise testing. Forty-eight age- and sex-matched healthy volunteers served as the control group. Compared to controls, maximal workload and peak oxygen consumption (VO2/kg) were lower in operated TOF patients (p < 0.001), whereas NT-proBNP concentration was elevated (p < 0.001). No difference was found among the other neurohormones. In operated TOF patients, NT-proBNP showed a significant positive correlation with right ventricular (RV) end systolic and end diastolic volumes and RV systolic pressure, and it showed a negative correlation with peak VO2/kg and RV ejection fraction. From multivariable analysis, NT-proBNP concentration was found to be an independent predictor of peak VO2/kg, RV end systolic volume, and RV systolic pressure. These results show an association among RV overload, decrease in functional capacity, and cardiac natriuretic peptide expression in operated TOF patients. NT-proBNP plasma assay may be a useful tool for diagnostic purposes and for decision making in this setting. |
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Authors:
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P Festa; L Ait-Ali; C Prontera; D De Marchi; M Fontana; M Emdin; C Passino |
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Publication Detail:
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Type: Journal Article Date: 2007-06-29 |
Journal Detail:
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Title: Pediatric cardiology Volume: 28 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-09-17 Completed Date: 2007-12-20 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 339-45 Citation Subset: IM |
Affiliation:
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Pediatric Cardiology and Cardiac Surgery Department, G. Pasquinucci Hospital, Via Aurelia Sud, Loc. Montepepe, 54100 Massa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Area Under Curve Child Child, Preschool Cross-Sectional Studies Echocardiography, Doppler Female Humans Magnetic Resonance Imaging Male Multivariate Analysis Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prospective Studies ROC Curve Tetralogy of Fallot / physiopathology*, surgery Ventricular Dysfunction, Right / diagnosis*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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