Document Detail


Amino acids, then and now--a reflection on Sir Hans Krebs' contribution to nitrogen metabolism.
MedLine Citation:
PMID:  11895074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
H. A. Krebs made an enormous contribution to our knowledge of amino acid metabolism, beginning with his studies on proteolysis in the early 1930s, progressing through his work on urea synthesis to an extensive series of papers on deamination and, then, to work on gluconeogenesis from amino acids. This paper addresses three of Krebs' early contributions-urea synthesis, glutamine metabolism, and D-amino acid oxidase-and relates them to our modern understanding of amino acid metabolism.
Authors:
J T Brosnan
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Publication Detail:
Type:  Biography; Historical Article; Journal Article    
Journal Detail:
Title:  IUBMB life     Volume:  52     ISSN:  1521-6543     ISO Abbreviation:  IUBMB Life     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-15     Completed Date:  2002-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Memorial University of Newfoundland, St John's, Canada. jbrosnan@mun.ca
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / history*,  metabolism
Biochemistry / history
D-Amino-Acid Oxidase / history,  metabolism
Glutamine / history,  metabolism
History, 20th Century
Models, Biological
Nitrogen / history,  metabolism
Urea / history,  metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 56-85-9/Glutamine; 57-13-6/Urea; 7727-37-9/Nitrogen; EC 1.4.3.3/D-Amino-Acid Oxidase
Personal Name Subject
Personal Name Subject:
H Krebs

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