Document Detail

Amino acids and peptides. XXV. Preparation of fibronectin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis.
MedLine Citation:
PMID:  8582015     Owner:  NLM     Status:  MEDLINE    
Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined. The inhibitory effect of RGD was markedly potentiated by hybrid formation with poly(ethylene glycol) #6000. As to inhibitory effect, RGD was more potent than RGDS and RGD PEG hybrids were superior to RGDS PEG hybrids. Hybrid formation with PEG #6000 was more effective than that with PEG #4000.
K Kawasaki; M Namikawa; Y Yamashiro; Y Iwai; T Hama; Y Tsutsumi; S Yamamoto; S Nakagawa; T Mayumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  43     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  2133-8     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan.
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MeSH Terms
Amino Acid Sequence
Antineoplastic Agents / chemical synthesis,  pharmacology*
Dose-Response Relationship, Drug
Fibrinogen / chemical synthesis,  pharmacology*
Lung Neoplasms / chemically induced,  drug therapy
Molecular Sequence Data
Neoplasm Metastasis / prevention & control*
Oligopeptides / chemical synthesis,  pharmacology*
Polyethylene Glycols / chemical synthesis,  pharmacology*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Oligopeptides; 0/Polyethylene Glycols; 9001-32-5/Fibrinogen; 91037-65-9/arginyl-glycyl-aspartyl-serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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