| Amino acids-nucleotides biomolecular recognition: from biological occurrence to affinity chromatography. | |
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MedLine Citation:
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PMID: 21038352 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In this review, the protein-DNA interactions are discussed considering different perspectives, and the biological occurrence of this interaction is explained at atomic level. The evaluation of the amino acid-nucleotide recognition has been investigated analysing datasets for predicting the association preferences and the geometry that favours the interaction. Based on this knowledge, an affinity chromatographic method was developed also exploiting this biological favoured contact. In fact, the implementation of this technique brings the possibility to apply the concept of molecular interactions to the development of new purification methodologies. In addition, the integration of the information recovered by all the different perspectives can bring new insights about some biological mechanisms, though not totally clarified. |
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Authors:
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F Sousa; C Cruz; J A Queiroz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of molecular recognition : JMR Volume: 23 ISSN: 1099-1352 ISO Abbreviation: J. Mol. Recognit. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004580 Medline TA: J Mol Recognit Country: England |
Other Details:
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Languages: eng Pagination: 505-18 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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CICS-Centro de Investigação em Ciências da Saúde, University of Beira Interior, 6201-001 Covilhã, Portugal. fani.sousa@fcsaude.ubi.pt |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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