Document Detail

Amino acids in cerebrospinal and brain interstitial fluid in experimental pneumococcal meningitis.
MedLine Citation:
PMID:  8099728     Owner:  NLM     Status:  MEDLINE    
Excitatory amino acids are increasingly implicated in the pathogenesis of neuronal injury induced by a variety of CNS insults, such as ischemia, trauma, hypoglycemia, and epilepsy. Little is known about the role of amino acids in causing CNS injury in bacterial meningitis. Several amino acids were measured in cerebrospinal fluid and in microdialysis samples from the interstitial fluid of the frontal cortex in a rabbit model of pneumococcal meningitis. Cerebrospinal fluid concentrations of glutamate, aspartate, glycine, taurine, and alanine increased significantly in infected animals. Among the amino acids with known excitatory or inhibitory function, interstitial fluid concentrations of glutamate were significantly elevated (by 470%). Alanine, a marker for anaerobic glycolysis, also increased in the cortex of infected rabbits. The elevated glutamate concentrations in the brain extracellular space suggest that excitotoxic neuronal injury may play a role in bacterial meningitis.
L Guerra-Romero; J H Tureen; M A Fournier; V Makrides; M G Täuber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  33     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-15     Completed Date:  1993-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  510-3     Citation Subset:  IM    
Infectious Diseases Laboratories, San Francisco General Hospital, California.
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MeSH Terms
Amino Acids / cerebrospinal fluid,  metabolism*
Brain / metabolism
Disease Models, Animal
Extracellular Space / metabolism
Glutamates / cerebrospinal fluid,  metabolism
Glutamic Acid
Meningitis, Pneumococcal / cerebrospinal fluid,  etiology,  metabolism*
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 56-86-0/Glutamic Acid

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