Document Detail

Amino acids in amniotic fluid in the 15th-16th weeks of gestation and preterm labor.
MedLine Citation:
PMID:  17437224     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate amino acids in amniotic fluid collected at the time of genetic amniocentesis. METHODS: We analyzed 128 fluids from the 15(th) week of gestation and 53 from the 16(th) week of gestation from normal pregnancies, and eight in the 15(th) week and seven in the 16(th) week from pregnancies that lead to preterm deliveries. We calculated the mean values for each week and the ratios between each pair of amino acids. The data for both groups (normal and preterm delivery) were compared. RESULTS: The most abundant amino acid in both groups was alanine. The comparisons of the groups showed significant differences for isoleucine in the 15(th) gestational week (p<0.05). Some amino acids had different evolutions between both gestational ages on comparing the normal group and preterm group. Eighteen ratios in the 15(th) week showed significant differences (mainly in the ratios of arginine and taurine), and three in the 16(th) week. CONCLUSIONS: The amino acid profiles in amniotic fluid, particularly in the 15(th) week of gestation, showed differences in the pregnancies that lead to preterm delivery.
C López Ramón Y Cajal; R Ocampo Martínez; E Couceiro Naveira; M Martínez
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  20     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
Prenatal Diagnosis Unit, Xeral Hospital, Vigo, Spain.
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MeSH Terms
Amino Acids / analysis*
Amniotic Fluid / chemistry*
Gestational Age
Obstetric Labor, Premature / etiology*
Pregnancy Trimester, Second*
Reg. No./Substance:
0/Amino Acids

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