| Amino acids fail to prevent halothane depression of albumin synthesis: studies in the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 1984365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Halothane (1.3 MAC) and ethanol (0.4%) depress albumin synthesis in isolated perfused rat livers (IPRLs). Addition of amino acids prevents depression by ethanol. We have examined the effects of amino acids on albumin synthesis by IPRLs exposed to halothane. Seventeen livers were perfused with a mixture of rat erythrocytes and rabbit plasma. Five were exposed to oxygen/carbon dioxide alone and 12 to oxygen/carbon dioxide with 1.5% halothane. A mixture of 10 essential amino acids was added to the perfusate of six of the halothane-exposed livers to a concentration approximately 10 times the normal rat plasma level. Perfusate concentrations of newly synthesized albumin were measured by radial immunodiffusion, and the rate of synthesis for the 4.25-h study period was calculated. The mean +/- SEM albumin synthetic rate (mg/h per 300-g rat) in the control group (12.13 +/- 1.36) was significantly greater than in the group receiving halothane alone (6.98 +/- 0.92). Amino acid treatment failed to prevent halothane depression of albumin synthesis (8.68 +/- 0.84). Thus, although amino acids block ethanol depression of albumin synthesis, we could show no such effect in rat livers exposed to halothane. |
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Authors:
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J B Kruskal; J J Franks; R E Kirsch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 72 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-01-18 Completed Date: 1991-01-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-4 Citation Subset: AIM; IM |
Affiliation:
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UCT/MRC Liver Research Center, University of Cape Town Medical School, Observatory, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Essential
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pharmacology* Animals Depression, Chemical Halothane / antagonists & inhibitors* Liver Circulation / drug effects*, physiology Male Rats Serum Albumin / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Essential; 0/Serum Albumin; 151-67-7/Halothane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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