| Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation. | |
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MedLine Citation:
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PMID: 6117484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Of the amino acids that affect the activity of central neurons, aspartate and glutamate (which exert generally excitatory influences) and glycine, taurine, and gamma-aminobutyric acid (GABA) (which generally exert inhibitory influences) are the strongest neurotransmitter candidates. As with other putative transmitter substances, their effects on body temperature when injected into the cerebral ventricles or the preoptic hypothalamus tend to vary within and between species. These effects are uninterpretable without accompanying information regarding effector activity changes and the influences of dose and ambient temperature. Observations necessary for analysis of apparent action have been made in studies of the effects of intracerebroventricular injections of these amino acids into sheep. Aspartate and glutamate have similar excitatory effects on the neural pathways that activate both heat production and heat loss effectors. Glycine appears to be without effect. |
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Authors:
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J Bligh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Federation proceedings Volume: 40 ISSN: 0014-9446 ISO Abbreviation: Fed. Proc. Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372771 Medline TA: Fed Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2746-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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physiology* Animals Aspartic Acid / physiology Body Temperature Regulation* Brain / physiology* Glutamates / physiology Glutamic Acid Glycine / physiology Humans Models, Neurological Neurotransmitter Agents / physiology* Synapses / physiology* Taurine / physiology gamma-Aminobutyric Acid / physiology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Glutamates; 0/Neurotransmitter Agents; 107-35-7/Taurine; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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