| Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders? | |
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MedLine Citation:
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PMID: 17956316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The IIS (insulin/IGF (insulin-like growth factor) signalling) cascade has an important role in regulating normal development and physiology, as evidenced by its effects in a host of major human diseases including cancer, Type 2 diabetes and neurodegeneration. Recently, it has become clear that multiple types of local nutrient-sensing mechanisms have an impact on cellular insulin-sensitivity through the downstream kinase TOR (target of rapamycin). In vivo analysis in flies has surprisingly highlighted PATs (proton-assisted amino acid transporters) as having a uniquely potent role in regulating IIS/TOR activity and growth, potentially via a novel signalling mechanism. Other molecules such as the heterodimeric amino acid transporter, CD98, which provides the principal route for cellular uptake of leucine, an amino acid implicated in regulating TOR, also appear to have important effects. As our understanding of how nutrient sensing has an impact on IIS/TOR increases, novel targets to modulate aberrant IIS in disease are likely to emerge, which could complement current strategies designed to block kinases in this pathway. |
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Authors:
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B Reynolds; R Laynes; M H Ogmundsdóttir; C A R Boyd; D C I Goberdhan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 35 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-24 Completed Date: 2008-02-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 1215-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Transport Systems
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metabolism* Humans Insulin / metabolism* Metabolic Diseases / drug therapy*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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A6174//Cancer Research UK; A6181//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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0/Amino Acid Transport Systems; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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