Document Detail


Amino acid transport into cultured McCoy cells infected with Chlamydia trachomatis.
MedLine Citation:
PMID:  10948179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amino acid transport into McCoy cells infected with strains representative of the two major biovars of Chlamydia trachomatis has been studied to determine if uptake is increased during infection. Preliminary work suggested that the transport systems L, A/ASC (for neutral amino acid transport), N (for transport of Asn, Gln, and His) and y+ (for cationic amino acids) were present in McCoy cells. With lymphogranuloma venereum biovar strain 434, little difference in the influx of representative amino acids Trp, His, and Lys or the analogue 2-aminoisobutyric acid (AIB) was observed during infection. With trachoma biovar strain DK20, a small increase in the initial entry rate and equilibrium concentration of each amino acid was found. McCoy cells appear to have great capacity for concentrating amino acids, which might obviate the need for transport induction by chlamydiae under conditions favoring the growth of infectious organisms.
Authors:
A Harper; C I Pogson; J H Pearce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  68     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5439-42     Citation Subset:  IM    
Affiliation:
Microbial Molecular Genetics and Cell Biology Group, School of Biological Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom. Angela.Harper@southroad.freeserve.co.uk
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Biological Transport
Cells, Cultured
Chlamydia trachomatis / physiology*
Fibroblasts / metabolism,  microbiology
Mice
Chemical
Reg. No./Substance:
0/Amino Acids
Comments/Corrections

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