Document Detail

Amino acid transport into cultured McCoy cells infected with Chlamydia trachomatis.
MedLine Citation:
PMID:  10948179     Owner:  NLM     Status:  MEDLINE    
Amino acid transport into McCoy cells infected with strains representative of the two major biovars of Chlamydia trachomatis has been studied to determine if uptake is increased during infection. Preliminary work suggested that the transport systems L, A/ASC (for neutral amino acid transport), N (for transport of Asn, Gln, and His) and y+ (for cationic amino acids) were present in McCoy cells. With lymphogranuloma venereum biovar strain 434, little difference in the influx of representative amino acids Trp, His, and Lys or the analogue 2-aminoisobutyric acid (AIB) was observed during infection. With trachoma biovar strain DK20, a small increase in the initial entry rate and equilibrium concentration of each amino acid was found. McCoy cells appear to have great capacity for concentrating amino acids, which might obviate the need for transport induction by chlamydiae under conditions favoring the growth of infectious organisms.
A Harper; C I Pogson; J H Pearce
Related Documents :
15689029 - Extraction and transport of chromium(vi) through a bulk liquid membrane containing trip...
5904589 - Movement of indoleacetic acid in coleoptiles of avena sativa l. ii. suspension of polar...
646179 - Percutaneous indirect lymphography with a new experimental contrast medium: a prelimina...
8288599 - Expression cloning and characterization of the hamster ileal sodium-dependent bile acid...
932019 - Opposing effects of mitogenic and nonmitogenic lectins on lymphocyte activation. eviden...
16496379 - L-type amino acid transporter 1 as a potential molecular target in human astrocytic tum...
3085109 - Metabolism of arachidonic acid by hamster trachea lack of stimulation by a23187.
19877629 - Nitrile ylides: diastereoselective cycloadditions using chiral oxazolidinones without l...
17994689 - Partial purification of latent polyphenol oxidase from peach (prunus persica l. cv. cat...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  68     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5439-42     Citation Subset:  IM    
Microbial Molecular Genetics and Cell Biology Group, School of Biological Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids / metabolism*
Biological Transport
Cells, Cultured
Chlamydia trachomatis / physiology*
Fibroblasts / metabolism,  microbiology
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cl(-) secretion in colonic epithelial cells induced by the vibrio parahaemolyticus hemolytic toxin r...
Next Document:  Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus...