Document Detail

Amino acid transport in the goldfish intestine.
MedLine Citation:
PMID:  5963739     Owner:  NLM     Status:  MEDLINE    
1. The serosal transfer of the following eight amino acids: threonine, alanine, serine, histidine, valine, methionine, phenylalanine and leucine, was measured using everted sacs of anterior intestine taken from goldfish acclimatized to 8 degrees C and incubated at 25 degrees C.2. All eight amino acids were actively transported and the serosal transfer correlated with the steady potential (P < 0.001) and with the amino acid-evoked potential (P < 0.05) measured on the same preparations.3. The goldfish rectum actively transported alanine and the steady potential was raised when alanine bathed the mucosa of the everted preparation.4. L-aspartic acid was partly transaminated to alanine by the goldfish anterior intestine; the rectum transaminated alanine to an unidentified amino acid which might have been serine, asparagine or glutamine or some mixture of these three.5. It is suggested that L-amino acids increase the ease by which sodium enters the mucosal cell but that it is the rate at which this sodium is transported across the basal membrane which determines the net serosal transfer of amino acids.
T B Mepham; M W Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  184     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1966 Jun 
Date Detail:
Created Date:  1967-05-31     Completed Date:  1967-05-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  673-84     Citation Subset:  IM    
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MeSH Terms
Alanine / metabolism*
Biological Transport, Active*
Histidine / metabolism*
Intestines / metabolism*
Leucine / metabolism*
Methionine / metabolism*
Phenylalanine / metabolism*
Serine / metabolism*
Threonine / metabolism*
Valine / metabolism*
Reg. No./Substance:
56-41-7/Alanine; 56-45-1/Serine; 61-90-5/Leucine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 7004-03-7/Valine; 71-00-1/Histidine; 72-19-5/Threonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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