Document Detail

Amino acid transport by a muscle cell line.
MedLine Citation:
PMID:  571529     Owner:  NLM     Status:  MEDLINE    
An established rat muscle cell culture, L-6, was employed for the evaluation of muscle amino acid transport. The initial influx of 16 radiolabeled amino acids into these cells was determined, and an overall uptake profile was constructed. L-6 cells accumulate amino acids progressively with time by saturable, temperature-dependent processes. As found in other preparations, several amino acids have sodium-dependent uptake systems. There is a wide range in the rate of transport of the different amino acids. The overall profile of uptake is fairly reproducible and may be characteristic of muscle tissue; it does not resemble that previously found in other cell types. The profile of amino acid uptake into these cells compares favorably with the pattern of amino acid transfer from the bloodstream to muscle found in intact rats. It is concluded that muscle cell transport is basically similar to that of other cell types. L-6 muscle cells have an amino acid uptake profile which resembles that of intact muscle; they should thus prove useful in the further delineation of muscle amino acid transport mechanisms.
W J Logan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  1     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  206-12     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism*
Biological Transport
Cell Line
Cell Membrane Permeability
Muscles / metabolism*
Sodium / physiology
Reg. No./Substance:
0/Amino Acids; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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