Document Detail


Amino acid signalling upstream of mTOR.
MedLine Citation:
PMID:  23361334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that is part of mTOR complex 1 (mTORC1), a master regulator that couples amino acid availability to cell growth and autophagy. Multiple cues modulate mTORC1 activity, such as growth factors, stress, energy status and amino acids. Although amino acids are key environmental stimuli, exactly how they are sensed and how they activate mTORC1 is not fully understood. Recently, a model has emerged whereby mTORC1 activation occurs at the lysosome and is mediated through an amino acid sensing cascade involving RAG GTPases, Ragulator and vacuolar H(+)-ATPase (v-ATPase).
Authors:
Jenna L Jewell; Ryan C Russell; Kun-Liang Guan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2013-01-30
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  14     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-12     Revised Date:  2014-04-17    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Autophagy
Cell Proliferation
Humans
Leucine-tRNA Ligase / metabolism
Lysosomes / metabolism*
Models, Biological
Monomeric GTP-Binding Proteins / metabolism
Multiprotein Complexes
Neuropeptides / metabolism
Proteins / metabolism*
Signal Transduction*
TOR Serine-Threonine Kinases / metabolism*
Grant Support
ID/Acronym/Agency:
CA108941/CA/NCI NIH HHS; R01 GM051586/GM/NIGMS NIH HHS; T32CA121938/CA/NCI NIH HHS; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Multiprotein Complexes; 0/Neuropeptides; 0/Proteins; 0/RHEB protein, human; 0/mechanistic target of rapamycin complex 1; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 3.6.5.2/Monomeric GTP-Binding Proteins; EC 6.1.1.4/Leucine-tRNA Ligase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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