| Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF. | |
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MedLine Citation:
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PMID: 19748348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this issue of Molecular Cell, Binda et al. identify Vam6/Vps39 as a guanine nucleotide exchange factor for Gtr1, a Rag family GTPase, to promote TORC1 activation in response to amino acids. |
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Authors:
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Li Li; Kun-Liang Guan |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Molecular cell Volume: 35 ISSN: 1097-4164 ISO Abbreviation: Mol. Cell Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2009-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9802571 Medline TA: Mol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 543-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, 92093, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Vesicular Transport
/
genetics,
metabolism* Amino Acids / metabolism* DNA-Binding Proteins / metabolism Endosomes / enzymology Guanine Nucleotide Exchange Factors / genetics, metabolism* Guanosine Diphosphate / metabolism Guanosine Triphosphate / metabolism Humans Intracellular Membranes / enzymology Monomeric GTP-Binding Proteins / genetics, metabolism* Multiprotein Complexes Protein Kinases / metabolism Protein-Serine-Threonine Kinases / metabolism* Saccharomyces cerevisiae / enzymology*, genetics, growth & development Saccharomyces cerevisiae Proteins / genetics, metabolism* Signal Transduction* Transcription Factors / metabolism Vacuoles / enzymology |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Vesicular Transport; 0/Amino Acids; 0/CRTC1 protein, human; 0/DNA-Binding Proteins; 0/GTR2 protein, S cerevisiae; 0/Gtr1 protein, S cerevisiae; 0/Guanine Nucleotide Exchange Factors; 0/MEH1 protein, S cerevisiae; 0/Multiprotein Complexes; 0/SWI4 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 0/Tco89 protein, S cerevisiae; 0/Transcription Factors; 0/VAM6 protein, S cerevisiae; 146-91-8/Guanosine Diphosphate; 86-01-1/Guanosine Triphosphate; EC 2.7.1.-/mTOR protein; EC 2.7.1.37/Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/target of rapamycin protein, S cerevisiae; EC 3.6.5.2/Monomeric GTP-Binding Proteins |
| Comments/Corrections | |
Comment On:
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Mol Cell. 2009 Sep 11;35(5):563-73
[PMID:
19748353
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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