| Amino acid sequence predicts folding rate for middle-size two-state proteins. | |
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MedLine Citation:
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PMID: 16477599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The significant correlation between protein folding rates and the sequence-predicted secondary structure suggests that folding rates are largely determined by the amino acid sequence. Here, we present a method for predicting the folding rates of proteins from sequences using the intrinsic properties of amino acids, which does not require any information on secondary structure prediction and structural topology. The contribution of residue to the folding rate is expressed by the residue's Omega value. For a given residue, its Omega depends on the amino acid properties (amino acid rigidity and dislike of amino acid for secondary structures). Our investigation achieves 82% correlation with folding rates determined experimentally for simple, two-state proteins studied until the present, suggesting that the amino acid sequence of a protein is an important determinant of the protein-folding rate and mechanism. |
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Authors:
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Ji-Tao Huang; Jing Tian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proteins Volume: 63 ISSN: 1097-0134 ISO Abbreviation: Proteins Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8700181 Medline TA: Proteins Country: United States |
Other Details:
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Languages: eng Pagination: 551-4 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Biochemistry, Tianjin University of Technology, Tianjin, China. jthuang@tjut.edu.cn |
| Data Bank Information | |
Bank Name/Acc. No.:
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PDB/1AEY; 1BNZ; 1C8C; 1CIS; 1COA; 1HDN; 1L2Y; 1L8W; 1MJC; 1NYF; 1POH; 1PSE; 1PSF; 1SHF; 1SHG; 3MEF |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence* Databases, Protein Predictive Value of Tests Protein Folding* Protein Structure, Secondary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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