Document Detail


Amino acid sequence coevolution in the insect bursicon ligand-receptor system.
MedLine Citation:
PMID:  22373512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pattern of amino acid residue replacement in the components of the bursicon signaling system (involving the BURSα/BURSβ heterodimer and its receptor BURSrec) was reconstructed across a phylogeny of 17 insect species, in order to test for the co-occurrence of replacements at sets of individual sites. Sets of three or more branches with perfectly concordant changes occurred to a greater extent than expected by chance, given the observed level of amino acid change. The latter sites (SPC sites) were found to have distinctive characteristics: (1) the mean number of changes was significantly lower at SPC sites than that at other sites with multiple changes; (2) SPC sites had a significantly greater tendency toward parallel amino acid changes than other sites with multiple changes, but no greater tendency toward convergent changes; and (3) parallel changes tended to involve relatively similar amino acids, as indicated by relatively low mean chemical distances. The results implicated functional constraint, permitting only a limited subset of amino acids in a given site, as a major factor in causing both parallel amino acid replacement and coordinated amino acid changes in different sites of the same protein and of interacting proteins in this system.
Authors:
Austin L Hughes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-21
Journal Detail:
Title:  Molecular phylogenetics and evolution     Volume:  63     ISSN:  1095-9513     ISO Abbreviation:  Mol. Phylogenet. Evol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-23     Completed Date:  2012-08-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9304400     Medline TA:  Mol Phylogenet Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Biological Sciences, University of South Carolina, Columbia, SC 29205, USA. austin@biol.sc.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Computer Simulation
Evolution, Molecular*
Insect Proteins / genetics*
Insects / genetics*
Invertebrate Hormones / genetics*
Phylogeny
Protein Structure, Tertiary / genetics
Receptors, G-Protein-Coupled / genetics*
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
GM43940/GM/NIGMS NIH HHS; R01 GM043940/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Insect Proteins; 0/Invertebrate Hormones; 0/Receptors, G-Protein-Coupled; 9041-06-9/bursicon
Comments/Corrections

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