Document Detail

Amino acid sensing mechanisms: an Achilles heel in cancer?
MedLine Citation:
PMID:  22686629     Owner:  NLM     Status:  MEDLINE    
The act of increasing mass, either in non-dividing cells or in dividing cells seeking to provide new material for daughter cells, depends upon the continued presence of extracellular nutrients in order to conserve mass. For amino acid nutrients, it appears that their insufficiency for new protein synthesis is actively monitored by both prokaryotic and eukaryotic cells, eliciting appropriate cellular responses that may depend not only on bulk nutrient supply, but also on the abundance of specific amino acids.
Richard F Lamb
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-03
Journal Detail:
Title:  The FEBS journal     Volume:  279     ISSN:  1742-4658     ISO Abbreviation:  FEBS J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-09-26     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  101229646     Medline TA:  FEBS J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2624-31     Citation Subset:  IM    
Copyright Information:
© 2012 The Author Journal compilation © 2012 FEBS.
Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Ave., Edmonton, Alberta, Canada.
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MeSH Terms
Amino Acids / metabolism*
Bacteria / metabolism
Fungi / metabolism
Lysosomes / metabolism
Neoplasms / metabolism*,  pathology
Proteins / metabolism
Quorum Sensing
Receptors, Amino Acid / metabolism
Signal Transduction
Reg. No./Substance:
0/Amino Acids; 0/Proteins; 0/Receptors, Amino Acid; 0/mechanistic target of rapamycin complex 1

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