| Amino acid sensing and mTOR regulation: inside or out? | |
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MedLine Citation:
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PMID: 19143641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signalling on a number of major human diseases and has helped to drive research to understand how TOR (target of rapamycin) is itself regulated. While it is clear that amino acids can affect TOR signalling, how these molecules are sensed by TOR remains controversial, perhaps because cells use different mechanisms as environmental conditions change. Even the question of whether they have an effect inside the cell or at its surface remains unresolved. The present review summarizes current ideas and suggests ways in which some of the models proposed might be unified to produce an amino acid detection system that can adapt to environmental change. |
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Authors:
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Deborah C I Goberdhan; Margret H Ogmundsdóttir; Shubana Kazi; Bruno Reynolds; Shivanthy M Visvalingam; Clive Wilson; C A Richard Boyd |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 37 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-02-11 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 248-52 Citation Subset: IM |
Affiliation:
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Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. deborah.goberdhan@dpag.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Transport Systems
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metabolism Amino Acids / metabolism* Animals Food Humans Intercellular Signaling Peptides and Proteins / metabolism Models, Biological Protein Kinases / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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A6174//Cancer Research UK; A6181//Cancer Research UK; A9093//Cancer Research UK; C19591/A6181//PHS HHS; C7713/A6174//PHS HHS; //Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Amino Acid Transport Systems; 0/Amino Acids; 0/Intercellular Signaling Peptides and Proteins; EC 2.7.-/Protein Kinases; EC 2.7.1.-/mTOR protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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