Document Detail

Amino acid residues of core region of hepatitis B virus. Asymptomatic carriers versus patients with liver disease.
MedLine Citation:
PMID:  1912438     Owner:  NLM     Status:  MEDLINE    
Recent molecular biological studies have shown that mutations of hepatitis B virus (HBV) genes may have an important role in the pathogenesis of HBV-induced liver diseases. It has been suggested that the core antigen of HBV could be an immunologic target of cytotoxic T lymphocytes. In this study, nucleotide sequences encoding 183 amino acid residues of the core region of HBV were analysed in 4 asymptomatic healthy carriers and in 5 patients with chronic liver disease, in whom serum aminotransferase levels were fluctuating. A cluster of amino acid substitutions were found from codon 87 to 97 of the core region of HBV in all 5 patients with liver diseases. Such changes were not found in any of the asymptomatic carriers. These data suggest that the peptide sequence spanning 11 amino acid residues in this particular region may play an important role in the pathogenesis of B-viral liver disease, and could be an immunologic target of cytotoxic T lymphocytes.
T Ehata; M Omata; O Yokosuka; K Hosoda; M Ohto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  6     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-11-06     Completed Date:  1991-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  292-6     Citation Subset:  IM    
First Department of Medicine, Chiba University School of Medicine, Japan.
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MeSH Terms
Amino Acid Sequence / genetics
Base Sequence
Carrier State
DNA, Viral / genetics
Gene Amplification
Genes, Viral / genetics
Hepatitis B Core Antigens / genetics*
Hepatitis B virus / genetics*
Hepatitis, Chronic / immunology
Molecular Sequence Data
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis B Core Antigens

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