Document Detail


Amino acid release from the intermediate medial hyperstriatum ventrale (IMHV) of day-old chicks following a one-trial passive avoidance task.
MedLine Citation:
PMID:  11848718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indirect evidence has implicated glutamate and gamma-amino butyric acid in memory formation for one-trial passive avoidance learning. We have further examined this by following the time course of glutamate and gamma-amino butyric acid release from slices prepared from the intermediate medial hyperstriatum ventrale of day-old chicks (Ross 1 Chunky) trained to avoid a bead covered in the aversant methylanthranilate. At various times after training, slices of left and right intermediate medial hyperstriatum ventrale were incubated in medium containing 50 mM potassium chloride and amino acid release was determined. Thirty minutes after training there was a bilateral increase in calcium-dependent glutamate release in slices from methylanthranilate-trained chicks compared to those trained to peck water. This increase was sustained until 1 h in the left hyperstriatum when an increase in calcium-dependent gamma-amino butyric acid release was also apparent. Glutamate uptake was also enhanced in left hyperstriatum (30 and 60 min) and in the right at 30 min. In the right intermediate medial hyperstriatum ventrale of methylanthranilate birds glutamate release was increased from 3 to 6.5 h and gamma-amino butyric acid at 6.5 h: a time that corresponded to the mobilization of a late process required if long-term memory was to be formed. These results confirm that the amino acids glutamate and gamma-amino butyric acid are released from the intermediate hyperstriatum ventrale in a calcium-dependent, neurotransmitter-like manner. Furthermore, changes in the release of these two amino acids accompany memory formation for a one-trial learning task in the day-old chick.
Authors:
Jonathan N Daisley; Steven P R Rose
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  77     ISSN:  1074-7427     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-30     Revised Date:  2007-10-17    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-201     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science (USA).
Affiliation:
Brain Research Group, The Open University, Milton Keynes, MK7 6AA, United Kingdom. j_daisley@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Avoidance Learning / physiology*
Basal Ganglia / metabolism*
Calcium / metabolism
Chickens
Female
Glutamic Acid / metabolism*
Male
Mental Recall / physiology
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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