| Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing. | |
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MedLine Citation:
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PMID: 4397948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H(2)O(2) during phagocytosis and do not kill catalase positive bacteria, had peroxide-generating amino acid oxidase activity equal to that found in PMN homogenates from patients with bacterial infections. The precise metabolic and bactericidal role of amino acid oxidases in PMN remains uncertain. |
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Authors:
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M R Eckstein; R L Baehner; D G Nathan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 50 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1971 Sep |
Date Detail:
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Created Date: 1971-10-14 Completed Date: 1971-10-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1985-91 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Oxidoreductases
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blood* Animals Cell Fractionation D-Amino-Acid Oxidase / blood* Electrodes Female Granuloma / blood Guinea Pigs Humans Hydrogen Peroxide / metabolism Infection / blood Lymphadenitis / blood Male NAD / metabolism Neutrophils / enzymology*, metabolism Oxygen Consumption Phagocytosis Spectrophotometry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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53-84-9/NAD; 7722-84-1/Hydrogen Peroxide; EC 1.4.-/Amino Acid Oxidoreductases; EC 1.4.3.3/D-Amino-Acid Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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