| Amino acid neurotransmission: spotlight on synaptic vesicles. | |
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MedLine Citation:
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PMID: 1691873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The vesicle hypothesis describing quantal release of neurotransmitter at the cholinergic neuromuscular junction was introduced in 1956. Since then, the concept of vesicular storage and release of acetylcholine has become firmly established and extended to include other synapses and neurotransmitters. However, for the amino acids, which are the major class of neurotransmitters in the mammalian CNS, there was no direct experimental evidence of the participation of synaptic vesicles in neurotransmission. This area of research has now moved out of the shadows and this article discusses recent findings which indicate that amino acid neurotransmitters are accumulated and stored by synaptic vesicles in presynaptic nerve endings. |
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Authors:
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P R Maycox; J W Hell; R Jahn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in neurosciences Volume: 13 ISSN: 0166-2236 ISO Abbreviation: Trends Neurosci. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-05-29 Completed Date: 1990-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7808616 Medline TA: Trends Neurosci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 83-7 Citation Subset: IM |
Affiliation:
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Department of Neurochemistry, Max-Planck-Institute for Psychiatry, Martinsried, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacokinetics,
physiology* Animals Neurons / metabolism*, physiology Neurotransmitter Agents / pharmacokinetics, physiology* Synaptic Vesicles / metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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