Document Detail

Amino acid neurotransmission: spotlight on synaptic vesicles.
MedLine Citation:
PMID:  1691873     Owner:  NLM     Status:  MEDLINE    
The vesicle hypothesis describing quantal release of neurotransmitter at the cholinergic neuromuscular junction was introduced in 1956. Since then, the concept of vesicular storage and release of acetylcholine has become firmly established and extended to include other synapses and neurotransmitters. However, for the amino acids, which are the major class of neurotransmitters in the mammalian CNS, there was no direct experimental evidence of the participation of synaptic vesicles in neurotransmission. This area of research has now moved out of the shadows and this article discusses recent findings which indicate that amino acid neurotransmitters are accumulated and stored by synaptic vesicles in presynaptic nerve endings.
P R Maycox; J W Hell; R Jahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in neurosciences     Volume:  13     ISSN:  0166-2236     ISO Abbreviation:  Trends Neurosci.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-29     Completed Date:  1990-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Neurochemistry, Max-Planck-Institute for Psychiatry, Martinsried, FRG.
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MeSH Terms
Amino Acids / pharmacokinetics,  physiology*
Neurons / metabolism*,  physiology
Neurotransmitter Agents / pharmacokinetics,  physiology*
Synaptic Vesicles / metabolism*,  physiology
Reg. No./Substance:
0/Amino Acids; 0/Neurotransmitter Agents

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