Document Detail


Amino acid metabolism in the human fetus at term: leucine, valine, and methionine kinetics.
MedLine Citation:
PMID:  21857387     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Human fetal metabolism is largely unexplored. Understanding how a healthy fetus achieves its fast growth rates could eventually play a pivotal role in improving future nutritional strategies for premature infants. To quantify specific fetal amino acid kinetics, eight healthy pregnant women received prior to elective cesarean section at term, continuous stable isotope infusions of the essential amino acids [1-C,N]leucine, [U-C5]valine, and [1-C]methionine. Umbilical blood was collected after birth and analyzed for enrichments and concentrations using mass spectrometry techniques. Fetuses showed considerable leucine, valine, and methionine uptake and high turnover rates. α-Ketoisocaproate, but not α-ketoisovalerate (the leucine and valine keto-acids, respectively), was transported at net rate from the fetus to the placenta. Especially leucine and valine data suggested high oxidation rates, up to half of net uptake. This was supported by relatively low α-ketoisocaproate reamination rates to leucine. Our data suggest high protein breakdown and synthesis rates, comparable with, or even slightly higher than in premature infants. The relatively large uptakes of total leucine and valine carbon also suggest high fetal oxidation rates of these essential branched chain amino acids. ABBREVIATIONS:
Authors:
Chris H P van den Akker; Henk Schierbeek; Gardi Minderman; Andras Vermes; Ernst M Schoonderwaldt; Johannes J Duvekot; Eric A P Steegers; Johannes B van Goudoever
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics [C.H.P.A., H.S., G.M., J.B.G.], Department of Obstetrics and Gynecology [E.M.S., J.J.D., E.A.P.S.], Erasmus MC - Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands; Hospital Pharmacy [A.V.], Erasmus MC, 3000 CA Rotterdam, the Netherlands.
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