Document Detail

Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes.
MedLine Citation:
PMID:  15389298     Owner:  NLM     Status:  MEDLINE    
We investigated amino acid metabolism in the Zucker diabetic fatty (ZDF Gmi fa/fa) rat during the prediabetic insulin-resistant stage and the frank type 2 diabetic stage. Amino acids were measured in plasma, liver, and skeletal muscle, and the ratios of plasma/liver and plasma/skeletal muscle were calculated. At the insulin-resistant stage, the plasma concentrations of the gluconeogenic amino acids aspartate, serine, glutamine, glycine, and histidine were decreased in the ZDF Gmi fa/fa rats, whereas taurine, alpha-aminoadipic acid, methionine, phenylalanine, tryptophan, and the 3 branched-chain amino acids were significantly increased. At the diabetic stage, a larger number of gluconeogenic amino acids had decreased plasma concentrations. The 3 branched-chain amino acids had elevated plasma concentrations. In the liver and the skeletal muscles, concentrations of many of the gluconeogenic amino acids were lower at both stages, whereas the levels of 1 or all of the branched-chain amino acids were elevated. These changes in amino acid concentrations are similar to changes seen in type 1 diabetes. It is evident that insulin resistance alone is capable of bringing about many of the changes in amino acid metabolism observed in type 2 diabetes.
Enoka P Wijekoon; Craig Skinner; Margaret E Brosnan; John T Brosnan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  82     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-09-24     Completed Date:  2005-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  506-14     Citation Subset:  IM    
Department of Biochemistry, Memorial University of Newfoundland, St. John's, Canada.
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MeSH Terms
Amino Acids / blood,  metabolism*
Amino Acids, Branched-Chain / metabolism
Blood Glucose
Creatinine / blood
Diabetes Mellitus, Type 2 / metabolism*
Insulin / blood
Insulin Resistance*
Liver / metabolism
Muscle, Skeletal / metabolism
Rats, Zucker
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Blood Glucose; 11061-68-0/Insulin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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